The international conference New Frontiers in Structure-Based Drug Discovery  is jointly established by the European MSC Innovative Training Networks AEGIS and TASPPI at Convitto della Calza in Florence, Italy.


The meeting will run from 12:00 Mon, Sep 23 to  16:00, Wed, Sep 25, 2019



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Joint International Conference
New Frontiers in Structure-based Drug Discovery
Monday, Sep 23, 2019                            Key note lectures: 35+5 min, Talks: 15+5 min, Flash Talk: 2 min
12:45Welcome  Michael Sattler, Christian Ottmann
 SESSION 1 – Structure- and Fragment-based Drug Discovery
Chair: Christian Ottmann
13:00Keynote lecture: Stephen Fesik Cancer Drug Discovery Using Fragment-Based Methods and Structure-Based Design
13:40Francesco Bosica Mg2-assisted small-molecule stabilisation of 14-3-3 Protein-Protein Interactions.
14:00Barak Akabayov Development of antibacterial agents that target the ribosomal PTC of M. tuberculosis
14:20Christian Griesinger Modulation of aggregating proteins studied by NMR and beyond in neuro- and cellular degeneration
14:40Madita WolterDrug Discovery at the Boundary of Cancer and Infection
15:00Keynote lecture: Mike Hann‘PhABits – shining new light on fragment approaches for assessing target tractability'
15:40Coffee Break
 SESSION 1 – cont'd
Chair: Tomáš Obšil
16:10João Neves Nuclear Magnetic Resonance guided screening applied to the discovery of modulators of 14-3-3 Protein-Protein Interactions
16:30Stefan Hoerer Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule
16:50Keynote lecture: Edward TateFragment-guided discovery of an irresistible antiviral protein-protein interaction inhibitor
17:30Flash Talks


Poster Session 1 with drinks
Tuesday, Sep 24, 2018
 SESSION 2 – Intrinsically Disordered and Amyloidogenic Proteins
Chair: Isabelle Landrieu
09:00Keynote lecture: Birthe Kragelund Disordered Protein Complexes
09:40Orgeta Zeijneli A VHH directed against tau as a novel therapeutic approach in tauopathies
10:00Carlos Camacho Neuroprotection by small molecule inhibition of disordered peptide and syntaxin interaction
10:20Coffee Break
 SESSION 3 – Chemical biology, targeting & new concepts
Chair: Alex Dömling


Keynote lecture: Alessio Ciulli Targeted Protein Degradation with Small Molecules: How PROTACs work
11:30Felix HauschSelective FKBP51 inhibitors enabled by transient pocket binding
11:50Markella KonstantinidouDiscovery of proteolysis targeting chimeras for leucine-rich repeat kinase 2 (LRRK2)
12:10Nikolaos SgourakisNew tools for the analysis of polyclonal T cell repertoires using chaperone-mediated peptide exchange
12:30Valeria Napolitano Inhibition of glycosomal protein import: the sweet death of Trypanosoma
 SESSION 3 – cont'd
Chair:  Alex Dömling
14:20Keynote lecture: Michelle ArkinChemical Biology Approaches to Understanding the VCP/p97 Protein Interaction Network
15:00João EncarnaçãoBioengineering subunit B from Shiga Toxin 1 for intracellular drug delivery
 SESSION 4 – Peptides, natural products and non-small molecules
Chair: Andrew Wilson
15:20Keynote lecture: Ora Schueler-Furman Peptide as leads for targeted inhibition of interactions – How free, how determined?
16:00Helen Boyd Identification of a novel cyclic peptide that disrupts the homodimerization of the E3 ubiquitin ligase IDOL
16:20Coffee Break
 SESSION 4 – cont'd
Chair: Andrew Wilson
16:50Françoise OchsenbeinRational Design of Peptides and Foldamers inhibiting a New Epigenetic Target in Cancer
17:10Grzegorz DubinMacrocycle mediated inhibition of PD-1/PD-L1 immune checkpoint
17:30Katiuscia PaganoDesign of antiangiogenic agents targeting Fibroblast Growth Factors-2/Tyrosine-Kinase Receptor
17:50Federica De LeoDiflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
18:10Xiao-Ling Cockcroft New Paradigm for Finding Natural-product-like KRAS Inhibitors
18:30Keynote lecture: Patricia AducciFusicoccin and 14-3-3 proteins, a long story from plant pathology to drug design.
Poster Session 2 
Gala Dinner
Wednesday, Sep 25, 2018
 SESSION 5 – Computational Drug Discovery
Chair:Helena Danielson
09:00Keynote lecture: Rebecca WadeComputational Approaches to Protein Dynamics and Binding Kinetics for Drug Discovery
09:40Marcus GastreichDebunking a myth - Can σ-Holes Really Drive Affinity?
10:00Alessandro Paiardini Identification of small-molecule inhibitors of the Aurora-A/TPX2 complex
 SESSION 6 – Structural biology, biophysics & methods
Chair:Michael Nilges
10:20Sebastian Guenther Serial Crystallography for Ligand-Binding Studies
10:40Charlotte Softley Placing fragments with lanthanide tags using paramagnetic NMR
11:00Coffee Break
 SESSION 6 – cont'd
Chair: Michael Nilges
11:30Claire Munier Small molecule stabilization of the GR 14-3-3 protein-protein interaction (PPI)
11:50Daisy Paiva Because structure means function - Conformational changes in proteins measured with switchSENSE®
12:10Charlotte Hodson Expanding Crystallographic methods for Fragment-based Drug Design
12:30Keynote lecture: Jan Steyaert From Nanobodies to Megabodies for applications in cryo-EM
14:40Announcement of Posterprizes 
END/FAREWELL Michael Sattler, Christian Ottmann
Workshop BioSolveIT